Small Molecules in Oncology - Uwe M. Martens

Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer. TOC:Protein kinase inhibitors: Imatinib. Erlotinib. Axitinib. Lapatinib. Sorafenib. Sunitinib. Dasatinib. Nilotinib. Bosutinib.- Epigenetic modifiers: Decitabine. 5-Aza.- Cell cycle inhibitors: Bortezomib. Temsirolimus. PHA-739. Bl2536.- Other novel agents: Imetelstat. GDC-0449.

Tytuł: Small Molecules in Oncology
Autor:

Uwe M. Martens

Seria: Recent Results in Cancer Research
Data wydania: listopad 2009
Wydawca: Springer-Verlag GmbH
ISBN: 3642012213
EAN: 9783642012211
Wymiary: 235 x 155 x 20